Anti-ATM (phospho S1981) antibody [10H11.E12] ab36810 from Abcam

Product Specs
ItemAnti-ATM (phospho S1981) antibody [10H11.E12]
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab36810
Quantity10 UG, 100 UG
ApplicationsFlow Cytometry, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Western blot, Flow Cytometry, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Western blot
Conjugate/TagUnconjugated
HostMouse, Nude mouse
Antibody TypePrimary
ClonalityMonoclonal
ModificationsPhospho-S1981
Clone10H11.E12
Research AreaEpigenetics
Gene NameATM
ReactivityHuman
TargetATM

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Abcam

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Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

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Website: http://www.abcam.com

(1) The fructose-bisphosphate, Aldolase A (ALDOA), facilitates DNA-PKcs and ATM kinase activity to regulate DNA double-strand break repairScientific reportsSeptember 13, 2023Sobanski T, Suraweera A, Burgess JT, Richard I, Cheong CM, Dave K, Rose M, Adams MN, O''Byrne KJ, Richard DJ, et al.for WB 1:1000), anti-P-ATM S1981 (5883, Cell Signaling Technology, for WB 1:1000), Anti-P-ATM S1981 (ab36810, Abcam for IF: 1:200) anti-γH2AX (ab26350, Abcam, for WB and IF 1:1000), anti-p-DNA-PK S2056 (ab124918,

(2) Molecular portraits of cell cycle checkpoint kinases in cancer evolution, progression, and treatment responsivenessScience advancesJune 30, 2023Oropeza E, Seker S, Carrel S, Mazumder A, Lozano D, Jimenez A, VandenHeuvel SN, Noltensmeyer DA, Punturi NB, Lei JT, et al.catalog no. 2197), Chk2 (Cell Signaling Technology, catalog no. 2662), phospho-ATM (Abcam, catalog no. ab36810), and glyceraldehyde phosphate dehydrogenase (Santa Cruz Biotechnology, catalog no. sc-47724). Survival

(3) Progression of irradiated mesenchymal stromal cells from early to late senescence: Changes in SASP composition and anti‐tumour propertiesCell ProliferationJune 1, 2023Nicola Alessio, Mustafa Burak Acar, Tiziana Squillaro, Domenico Aprile, Şerife Ayaz‐Güner, Giovanni Di Bernardo, Gianfranco Peluso, Servet Özcan, Umberto Galderisiantibodies against pH2A.X (Ser139) (1:600, 2577, Cell Signaling, Danvers, MA, USA) and pATM (S1981) (1:1000, ab36810, Abcam, Cambridge, UK) at 4°C O.N. in buffer solution (PBS1X, 5% BSA and 0.1% Triton X‐100). Nuclear

(4) Nuclear DJ-1 Regulates DNA Damage Repair via the Regulation of PARP1 ActivityInternational journal of molecular sciencesMay 12, 2023Wang ZX, Liu Y, Li YL, Wei Q, Lin RR, Kang R, Ruan Y, Lin ZH, Xue NJ, Zhang BR, et al.(#9532), anti-RAD51 (#8875), anti-PAR (#83732), and anti-histone H3 (#4499). Anti-phospho S1981-ATM (ab36810), anti-γH2AX (ab22551), and anti-DJ-1 (ab11251) were purchased from Abcam. Anti-β-actin (AC026) was

(5) Interaction between Cigarette Smoke and Human Papillomavirus 16 E6/E7 Oncoproteins to Induce SOD2 Expression and DNA Damage in Head and Neck CancerInternational Journal of Molecular SciencesApril 7, 2023Diego Carrillo-Beltrán, Julio C. Osorio, Rancés Blanco, Carolina Oliva, Enrique Boccardo, Francisco Aguayowith primary antibodies against p53 (BD554294) (BD PharmigenTM, San Diego, CA, USA), pRb (ab24), pATM (ab36810), ATM (ab78), (Abcam, Cambridge, UK), pAKT1S473 (4060S) (Cell Signaling, Danver, MA, USA), β-actin (SC47778),

(6) ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy ResistanceCancer researchDecember 16, 2022Mellone M, Piotrowska K, Venturi G, James L, Bzura A, Lopez MA, James S, Wang C, Ellis MJ, Hanley CJ, et al.IR61061-2 Dako); (ii) SMA (ready-to-use; AEC-RED; IR61161-2 Dako); (iii) pATM-ser1981 (1:200low AEC_RED; ab36810 Abcam); and (iv) CK (1:5; AE1/AE3; AEC_RED; IR05361-2, Dako). Multiplex images were generated using

(7) Alpha-actnin-4 (ACTN4) selectively affects the DNA double-strand breaks repair in non-small lung carcinoma cellsBiology directDecember 7, 2022Kriger D, Novitskaya K, Vasileva G, Lomert E, Aksenov ND, Barlev NA, Tentler D.USA), 53BP1 (NB100-304, Novus Biologicals, USA), pBRCA1 (9009, Cell Signaling, USA), pATM (Ser1981) (ab36810, Abcam, UK) were used. After being washed 3 times with the blocking buffer, the samples were incubated

(8) The Effect of Atm Loss on Radiosensitivity of a Primary Mouse Model of Pten-Deleted Brainstem GliomaCancersSeptember 17, 2022Stewart CE, Guerra-García ME, Luo L, Williams NT, Ma Y, Regal JA, Ghosh D, Sansone P, Oldham M, Deland K, et al.anti-human-ATM(phospho-S1981) which stains the homologous mouse ph-ATM(phosphor-S1987) was used at 1:500 (Abcam ab36810). The slides were incubated in biotin-conjugated secondary antibodies, then staining was visualized

(9) Ataxia telangiectasia mutated: The potential negative regulator in platelet-derived growth factor-BB promoted proliferation of pulmonary arterial smooth muscle cellsFrontiers in Cardiovascular MedicineAugust 3, 2022Chaoyi Qin, Yiheng Zan, Liang Xie, Hanmin Liublocked by using the fixing buffer and blocking buffer, respectively. Antiphosphorylated ATM antibody (ab36810, Abcam, USA) was used for incubation and detection at 4°C overnight. After removal of the primary antibody,

(10) Involvement of DNA Damage Response via the Ccndbp1-Atm-Chk2 Pathway in Mice with Dextran-Sodium-Sulfate-Induced ColitisJournal of clinical medicineJune 25, 2022Horigome R, Kamimura K, Niwa Y, Ogawa K, Mizuno KI, Fujisawa K, Yamamoto N, Takami T, Sugano T, Sakamaki A, et al.anti-Atm antibody (ab78; Abcam, Cambridge, UK) at 1:200 dilution; an anti-phospho S1981 Atm antibody (ab36810; Abcam, Cambridge, UK) at 1:50 dilution using the Vectastain Elite ABC mouse IgG kit (PK-6102; Vector Laboratories

(11) Novel Targeting of DNA Methyltransferase Activity Inhibits Ewing Sarcoma Cell Proliferation and Enhances Tumor Cell Sensitivity to DNA Damaging Drugs by Activating the DNA Damage ResponseFront Endocrinol (Lausanne)May 31, 2022Camilla Cristalli et al.sc-20703 lot # L0412, Santa Cruz Biotechnology, Dallas, TX, U.S.), anti-phospho-ATM (S1981) (1:2000, ab36810 lot# gr3185919-27, Abcam, Cambridge, UK), anti-p21 (1:1000, sc-6246 lot # E0511, Santa Cruz Biotechnology),

(12) Cyclin D1 Binding Protein 1 Responds to DNA Damage through the ATM–CHK2 PathwayJournal of Clinical MedicineFebruary 6, 2022Yusuke Niwa et al.1:1000 dilution; anti-ATM antibody (ab78, Abcam) at 1:2000 dilution; anti-phospho S1981 ATM antibody (ab36810, Abcam) at 1:1000 dilution, anti-Chk2 antibody (No. 2662, Cell Signaling Technology, Inc., Danvers,

(13) The cyclin dependent kinase inhibitor p21(Cip1/Waf1) is a therapeutic target in high-risk neuroblastomaFrontiers in oncologyJanuary 1, 2022Sorteberg AL, Halipi V, Wickström M, Shirazi Fard S.,Cell Signaling Technologies,1:1000 Anti-p21Waf1/Cip1 (phospho T145) (rabbit),ab47300,Abcam,1:1000 Anti-ATM (phospho S1981) (mouse),ab36810,Abcam,1:500 Anti-Ki67 (chicken),ab254123,Abcam,1:1000 Anti-C-Casp3 (Asp175) (rabbit),9661,Cell Signaling Technologies

(14) Significance of abnormal 53BP1 expression as a novel molecular pathologic parameter of follicular-shaped B-cell lymphoid lesions in human digestive tractScientific ReportsDecember 1, 2021Thi My Hanh Luong, Katsuya Matsuda, Daisuke Niino, Hirokazu Kurohama, Masahiro Ito, Masahiro NakashimaUK) or with monoclonal mouse anti-ataxia telangiectasia mutated (ATM; phospho S1981) antibody (1:500; ab36810; Abcam). The samples were then incubated with Alexa Fluor 488-conjugated goat anti-rabbit and Alexa

(15) Complete response to neoadjuvant chemoradiotherapy in rectal cancer is associated with RAS/AKT mutations and high tumour mutational burdenRadiation OncologyDecember 1, 2021Joanne D. Stockton, Louise Tee, Celina Whalley, Jonathan James, Mark Dilworth, Rachel Wheat, Thomas Nieto, Ian S-CORT Consortium, João D. Barros-Silva, Andrew D. Barros-Silva, et al.described using a Leica BondMax autostainer. IHC was performed against yH2AX (Abcam ref ab26350), ATM (ab36810), Ku70/80 (ab53126), MLH1 (ab92312), MSH2 (ab52266) and MSH6 (ab14204) and slides were then scanned

(16) Involvement of TRPM8 Channel in Radiation-Induced DNA Damage Repair Mechanism Contributing to Radioresistance of B16 MelanomaBiological & pharmaceutical bulletinMay 1, 2021Nomura D, Abe R, Tsukimoto M.Corporation. The primary antibodies used were ATM (phosphoS1981) (10H.E12) antibody (Abcam, U.K., #ab36810), rabbit antiTRPM8 antibody (Sigma, U.S.A. #HPA024117), p53 (D2H90) rabbit monoclonal antibody (mAb)

(17) Vitamin D Deficiency Induces Chronic Pain and Microglial Phenotypic Changes in MiceInternational journal of molecular sciencesMarch 30, 2021Alessio N, Belardo C, Trotta MC, Paino S, Boccella S, Gargano F, Pieretti G, Ricciardi F, Marabese I, Luongo L, et al.were incubated in a blocking solution with the antibodies Ki67 (sc-7846, Santa Cruz, TX, USA), or ATM (ab36810, ABCAM, UK) for O.N. at 4°C. Subsequently, cells were washed three times with PBS, before adding the

(18) Granzyme B Induces IRF-3 Phosphorylation through a Perforin-Independent Proteolysis-Dependent Signaling Cascade without Inducing Cell DeathJournal of immunology (Baltimore, Md. : 1950)January 15, 2021Gapud EJ, Trejo-Zambrano MI, Gomez-Banuelos E, Tiniakou E, Antiochos B, Granville DJ, Andrade F, Casciola-Rosen L, Rosen A.or dilution used) ATM,Cell Signaling Technologies (D2E2) #2873 (1:1000) Phospho-ATM (S1981),Abcam ab36810 (0.056 μg/mL) Cleaved Caspase-3 (Asp175),Cell Signaling Technologies #9661 (1:500) Cleaved Caspase-7

(19) Bifidobacterium infantis Maintains Genome Stability in Ulcerative Colitis via Regulating Anaphase-Promoting Complex Subunit 7Frontiers in microbiologyJanuary 1, 2021Han T, Hu X, Li K, Zhang D, Zhang Y, Li J.with the indicated antibodies, including γH2Ax (CST, Danvers, MA, United States, #9718), p-ATM (Abcam, ab36810) and APC7 (Santa Curze, sc-365649). cDNA Synthesis, Genomic DNA Extraction, and Quantitative Real-Time PCR

(20) Resolvin D1 attenuates the inflammatory process in mouse model of LPS-induced keratitisJournal of cellular and molecular medicineNovember 1, 2020Petrillo F, Trotta MC, Bucolo C, Hermenean A, Petrillo A, Maisto R, Pieretti G, Pietropaolo M, Ferraraccio F, Gagliano C, et al.(ATM) protein kinase (Mouse monoclonal anti‐ATM phospho S1981 antibody [10H11.E12]; dilution 1:1000; ab36810 Abcam), anti‐vimentin (Rabbit monoclonal anti‐vimentin antibody [EPR3776]; concentration 5 µg/mL; ab92547

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Anti-ATM (phospho S1981) antibody [10H11.E12] from Abcam

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Anti-ATM (phospho S1981) antibody [10H11.E12] from Abcam

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